What is Berberine?

The short answer

Berberine is a bitter yellow compound found in some plants, such as barberry.

  • What it is

    Alkaloid from barberry and goldenseal; activates AMPK in lab studies.

  • What people look into

    Weight

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What it is

Type
Plant isoquinoline alkaloid (botanical supplement)
Also known as
berberine hcl, berberine hydrochloride, natural ozempic, nature's ozempic
How it works
Alkaloid from barberry and goldenseal; activates AMPK in lab studies.

Regulatory status

Supplement How we label status

As of October 4, 2026, Berberine is sold in the US as a dietary supplement.

See Berberine in the Index →

Federal (FDA)
Not an approved drug; sold as a dietary supplement (no FDA statement that it is unlawful found)
WADA 2026
Not named on the 2026 List

References

Sources as of October 4, 2026

  1. FDA warning letter, January 21, 2026
  2. WADA: www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf