What is Gonadorelin?

The short answer

Gonadorelin is a lab-made form of the hormone that tells the body to make sex hormones.

What it is
Native GnRH; pulses stimulate LH and FSH release.
What people look into
Testosterone

5 sources
Status as of October 4, 2026
How we source
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By Ellum EditorialPublished October 6, 2026Updated October 11, 2026AI use

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Peptides: Gonadorelin (1 selected) · edit

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What it is

Type: GnRH (peptide)
Also known as: factrel, lutrepulse, gnrh, gonadorelin acetate
How it works: Native GnRH; pulses stimulate LH and FSH release.

Regulatory status

FDA-approved, discontinued How we label status

FDA status (as of October 4, 2026): Approved for people as Factrel in 1982 and Lutrepulse in 1989. Both have since been discontinued. The federal drug label site DailyMed lists gonadorelin only in drugs for animals

See Gonadorelin in the Index →

Federal (FDA): Approved for people as Factrel in 1982 and Lutrepulse in 1989. Both have since been discontinued. The federal drug label site DailyMed lists gonadorelin only in drugs for animals
503A compounding: No 503A category; 503B Category 1 as approved-drug component (as of March 21, 2025)
WADA 2026: S2.2.1 (males)

Timeline

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Date	What happened	Source
July 19, 1996	FDA final rule amends the animal drug regulations to reflect approval of an abbreviated application for a gonadorelin diacetate tetrahydrate solution for dairy cattle.	Federal Register, event of July 19, 1996, on federalregister.gov
November 13, 2002	FDA final rule amends the animal drug regulations to reflect approval of a second abbreviated application for a gonadorelin diacetate tetrahydrate solution for dairy cattle.	Federal Register, event of November 13, 2002, on federalregister.gov

US enforcement actions

1 US enforcement action, in 2026.

Actions by US federal and state agencies whose documents name Gonadorelin. Each row links to the government's own document.

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Date	Agency	Action	Document
June 17, 2026	FDA	Warning letter	FDA document, warning letter, June 17, 2026, on fda.gov

References

Sources as of October 4, 2026