What is Pramlintide?

The short answer

Pramlintide is a peptide, a short chain of amino acids. In the US, you need a prescription to get Pramlintide.

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What it is

Type
Amylin analog (peptide)
Also known as
symlin, symlinpen, amylin analog
How it works
Mimics amylin to slow stomach emptying and blunt post-meal glucose.

Regulatory status

FDA-approved (Rx) How we label status

As of October 4, 2026, Pramlintide is an FDA-approved prescription drug for type 1 and type 2 diabetes with mealtime insulin.

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Federal (FDA)
Approved Rx (Symlin NDA021332, 2005); manufacture discontinued (AstraZeneca, FDA drug shortage list, posted 2025-10-27); Drugs@FDA lists every strength Discontinued; listed marketing end date 2027-01-31
503A compounding
Approved-drug component (not in any 503A category) (as of May 14, 2026)

References

Sources as of October 4, 2026

  1. DailyMed: dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
  2. Drugs@FDA: www.accessdata.fda.gov/scripts/cder/daf/index.cfm
  3. FDA: www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm