What is Rapamycin (sirolimus)?

The short answer

In the US, you need a prescription to get Rapamycin (sirolimus).

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What it is

Type
mTOR inhibitor (not a peptide)
Also known as
rapamune, rapa, rapamycin longevity, low dose rapamycin, fyarro, hyftor

Regulatory status

FDA-approved (Rx) How we label status

As of October 4, 2026, Rapamycin (sirolimus) is an FDA-approved prescription drug for renal-transplant rejection prophylaxis.

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Federal (FDA)
Approved Rx (Rapamune NDA021083 1999 / NDA021110 2000; Fyarro NDA213312 2021; Hyftor gel; generics); label: renal-transplant rejection prophylaxis. Boxed warning. Longevity use is off-label
503A compounding
Approved-drug component (not in any 503A category) (as of May 14, 2026)
WADA 2026
Not named

References

Sources as of October 4, 2026

  1. DailyMed: dailymed.nlm.nih.gov/dailymed/drugInfo.cfm (1 of 2)
  2. DailyMed: dailymed.nlm.nih.gov/dailymed/drugInfo.cfm (2 of 2)