Cagrilintide / retatrutide stack: what's in it

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By Ellum EditorialPublished October 9, 2026Updated October 11, 2026AI use

The short answer

Cagrilintide / retatrutide stack combines Cagrilintide and Retatrutide.

What it is
Investigational incretin + amylin stack.
What people look into
Weight
Results for one compound don't tell you what the two do together.

The parts

Cagrilintide Index
Investigational (phase 3)

Retatrutide Index

Investigational (phase 3)

Retatrutide
Papers on animals	9
Lab-dish (cell) papers	none found
Papers PubMed tags as about people	110
Registered trials (ClinicalTrials.gov)	19 of 32 search results name Retatrutide
Randomized trials in people	7

Bars are counts of papers or trials; a longer bar means more studies, not better results. Study counts auto-counted from PubMed tags and ClinicalTrials.gov in the Ellum research database, as of October 6, 2026 (not reviewed; a paper can carry more than one tag). Papers PubMed tags as about people: includes reviews and case reports; not randomized trials. All bars share one scale. Each count is for that part alone.

Regulatory status by component

Not FDA-approved How we label status

As of October 4, 2026, Cagrilintide is not FDA-approved for any use and is not on FDA's 503A bulks list. It is in phase 3 trials. See Cagrilintide in the Index →
As of October 4, 2026, Retatrutide is not FDA-approved for any use and is not on FDA's 503A bulks list. It is in phase 3 trials. See Retatrutide in the Index →

Status as of October 4, 2026

As a combination: No category as a combination (see components)

Cagrilintide: as of October 4, 2026 · source
Retatrutide: as of October 4, 2026 · source

Timeline

Scroll sideways to see all columns.

Date	What happened	Source
December 10, 2024	FDA warning letter to an online seller names retatrutide and cagrilintide among products marketed on its website.	FDA (1 of 2), event of December 10, 2024, on fda.gov FDA (2 of 2), event of December 10, 2024, on fda.gov
December 8, 2025	FDA warning letter to a company names retatrutide and cagrilintide acetate among drugs the company distributed.	FDA, event of December 8, 2025, on fda.gov
March 31, 2026	FDA warning letter to an online seller names a cagrilintide product and a product identified as retatrutide.	FDA, event of March 31, 2026, on fda.gov
October 1, 2026	FDA page on unapproved GLP-1 drugs used for weight loss states that retatrutide and cagrilintide cannot be used in compounding under federal law.	FDA, event of October 1, 2026, on fda.gov

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The research on Cagrilintide / retatrutide stack

Key facts

Also known as: cagri reta, cagri reta stack, cagrilintide retatrutide

Parts: Cagrilintide and Retatrutide
Route: injectable

References

Status sources

Sources as of October 4, 2026

What this doesn’t establish

Results for one compound don't tell you what the two do together.