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CagriSema: what's in it

By Ellum EditorialPublished Updated AI use

The short answer

CagriSema combines Cagrilintide and Semaglutide.

  • What it is

    Pairs an amylin analog with a GLP-1 agonist.

  • What people look into

    Weight

    Results for one compound don't tell you what the two do together.

The parts

  • Cagrilintide Index

    Investigational (phase 3)

  • Semaglutide Index

    FDA-approved (Rx)

    WADA 2026: Not prohibited (monitoring)

    Papers on animals269
    Lab-dish (cell) papers4
    Papers PubMed tags as about people2,946
    Registered trials (ClinicalTrials.gov)624 of 778 search results name Semaglutide
    Randomized trials in people308

Bars are counts of papers or trials; a longer bar means more studies, not better results. Study counts auto-counted from PubMed tags and ClinicalTrials.gov in the Ellum research database, as of October 6, 2026 (not reviewed; a paper can carry more than one tag). Papers PubMed tags as about people: includes reviews and case reports; not randomized trials. All bars share one scale. Each count is for that part alone.

Regulatory status by component

Not FDA-approved How we label status

  • As of October 4, 2026, Cagrilintide is not FDA-approved for any use and is not on FDA's 503A bulks list. It is in phase 3 trials. See Cagrilintide in the Index →
  • As of October 4, 2026, Semaglutide is an FDA-approved prescription drug for type 2 diabetes; chronic weight management; cardiovascular risk reduction; reducing the risk of sustained eGFR decline, end-stage kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease, Ozempic injection only; noncirrhotic MASH with moderate to advanced liver fibrosis (stages F2 to F3) in adults, Wegovy injection only, under accelerated approval. See Semaglutide in the Index →

Status as of October 4, 2026

As a combination
Not eligible (cagrilintide component: FDA 'cannot be used in compounding')
  • Cagrilintide: as of October 4, 2026 · source
  • Semaglutide: as of October 4, 2026 · source

Timeline

Scroll sideways to see all columns.

DateWhat happenedSource
FDA warning letter to an online seller names semaglutide and cagrilintide among products marketed on its website.FDA
FDA warning letter to an online seller names a product described as cagrilintide and semaglutide, along with separate cagrilintide and semaglutide products.FDA
FDA warning letter to an online seller names a cagrilintide product and a product identified as semaglutide.FDA
FDA page on unapproved GLP-1 drugs used for weight loss discusses semaglutide and states that cagrilintide cannot be used in compounding under federal law.FDA

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The research on CagriSema (cagrilintide + semaglutide)

Key facts

Also known as: cagrilintide semaglutide

Parts
Cagrilintide and Semaglutide
Route
injectable

References

Status sources

Sources as of October 4, 2026

  1. FDA: api.fda.gov/drug/drugsfda.json
  2. FDA: www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss
  3. ClinicalTrials.gov: clinicaltrials.gov/study/NCT05567796

What this doesn’t establish

Results for one compound don't tell you what the two do together.