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Retatrutide / MOTS-c stack: what's in it

By Ellum EditorialUpdated AI use

The short answer

Retatrutide / MOTS-c stack combines Retatrutide and MOTS-c.

  • What it is

    Metabolic stack.

  • What people look into

    Weight, aging

    Results for one compound don't tell you what the two do together.

The parts

  • Retatrutide Index

    Investigational (phase 3)

    Papers on animals9
    Lab-dish (cell) papersnone found
    Papers PubMed tags as about people110
    Registered trials (ClinicalTrials.gov)19 of 32 search results name Retatrutide
    Randomized trials in people7

  • MOTS-c Index

    Not FDA-approved · advisory vote July 2026 · no FDA decision

    WADA 2026: S4.4.1

    Papers on animals54
    Lab-dish (cell) papers3
    Papers PubMed tags as about people143
    Registered trials (ClinicalTrials.gov)0 of 4 search results name MOTS-c
    Randomized trials in people4

Bars are counts of papers or trials; a longer bar means more studies, not better results. Study counts auto-counted from PubMed tags and ClinicalTrials.gov in the Ellum research database, as of October 6, 2026 (not reviewed; a paper can carry more than one tag). Papers PubMed tags as about people: includes reviews and case reports; not randomized trials. All bars share one scale. Each count is for that part alone.

Regulatory status by component

Not FDA-approved How we label status

  • As of October 4, 2026, Retatrutide is not FDA-approved for any use and is not on FDA's 503A bulks list. It is in phase 3 trials. See Retatrutide in the Index →
  • As of October 4, 2026, MOTS-c is not FDA-approved. On July 23, 2026, FDA's compounding advisory committee voted to recommend adding it to the 503A bulks list; FDA staff had recommended against it. FDA has not proposed that change. See MOTS-c in the Index →

Status as of October 4, 2026

As a combination
No category as a combination (see components)
  • Retatrutide: as of October 4, 2026 · source
  • MOTS-c: as of October 4, 2026 · source

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The research on Retatrutide / MOTS-c stack

Key facts

Also known as: retatrutide mots-c, elite metabolic stack, metabolic super stack

Parts
Retatrutide and MOTS-c
Route
injectable

References

Status sources

Sources as of October 4, 2026

  1. FDA: www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss
  2. FDA: www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026

What this doesn’t establish

Results for one compound don't tell you what the two do together.