What is Vasoactive intestinal peptide (VIP)?

The short answer

Vasoactive intestinal peptide, or VIP, is made by the body in the gut and in nerves.

  • What it is

    Studied for its action on smooth muscle in the lungs.

  • What people look into

    Brain

Get updates on Vasoactive intestinal peptide (VIP)

What it is

Type
Neuropeptide
Also known as
vip peptide, aviptadil
How it works
Studied for its action on smooth muscle in the lungs.

Regulatory status

Not FDA-approved How we label status

As of October 4, 2026, Vasoactive intestinal peptide (VIP) is not FDA-approved for any use and is not on FDA's 503A bulks list.

See Vasoactive intestinal peptide (VIP) in the Index →

Federal (FDA)
Not FDA-approved
503A compounding
Category 1 (interim; enforcement discretion); not on 216.23 as of 2026-10-07 (as of October 7, 2026)
PCAC history
2016-11-03: voted not to include (vote count not confirmed), FDA proposed exclusion 2019-09-05 (84 FR 46688), never finalized

Timeline

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Timeline table
DateWhat happenedSource
Federal Register notice of an FDA Pharmacy Compounding Advisory Committee meeting lists vasoactive intestinal peptide among bulk drug substances under consideration for the 503A bulks list.Federal Register, event of October 5, 2016, on federalregister.gov
FDA proposed rule lists vasoactive intestinal peptide among bulk drug substances it proposes not to include on the 503A bulks list.Federal Register, event of September 5, 2019, on federalregister.gov
FDA list of bulk drug substances nominated under section 503A, updated May 14, 2026, places vasoactive intestinal peptide in category 1, under evaluation.FDA, event of May 14, 2026, on fda.gov

References

Sources as of October 4, 2026

  1. FDA: www.fda.gov/media/94155/download
  2. Federal Register: www.federalregister.gov/d/2019-18951
  3. eCFR: www.ecfr.gov/current/title-21/chapter-I/subchapter-C/part-216/subpart-B/section-216.23