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NAD+ (oral precursors): what's in it

By Ellum EditorialUpdated AI use

The short answer

NAD+ (oral precursors) combines NMN, NR and TMG.

The parts

  • NMN (nicotinamide mononucleotide) Index

    Supplement

    Papers on animals466
    Lab-dish (cell) papers52
    Papers PubMed tags as about people555
    Registered trials (ClinicalTrials.gov)18 of 32 search results name NMN (nicotinamide mononucleotide)
    Randomized trials in people17

  • NR (nicotinamide riboside) Index

    Supplement

    Papers on animals258
    Lab-dish (cell) papers13
    Papers PubMed tags as about people383
    Registered trials (ClinicalTrials.gov)101 of 123 search results name NR (nicotinamide riboside)
    Randomized trials in people31

  • TMG (betaine) Index

    Supplement

Bars are counts of papers or trials; a longer bar means more studies, not better results. Study counts auto-counted from PubMed tags and ClinicalTrials.gov in the Ellum research database, as of October 6, 2026 (not reviewed; a paper can carry more than one tag). Papers PubMed tags as about people: includes reviews and case reports; not randomized trials. All bars share one scale. Each count is for that part alone.

Regulatory status by component

Supplement How we label status

Status as of October 4, 2026

  • NMN (nicotinamide mononucleotide): as of October 4, 2026 · source
  • NR (nicotinamide riboside): as of October 4, 2026 · source
  • TMG (betaine): as of October 4, 2026 · source

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The research on NAD+ (oral precursors)

Key facts

Also known as: nad supplement, nad precursor, nad+ supplement

Parts
NMN (nicotinamide mononucleotide), NR (nicotinamide riboside) and TMG (betaine)
Route
oral

References

Status sources

Sources as of October 4, 2026

  1. FDA: www.fda.gov/food/new-dietary-ingredient-ndi-notification-process/submitted-75-day-premarket-notifications-new-dietary-ingredients
  2. Regulations.gov: www.regulations.gov/document/FDA-2023-P-0872-2754
  3. Regulations.gov: www.regulations.gov/document/FDA-2022-S-0023-0068
  4. FDA: hfpappexternal.fda.gov/scripts/fdcc/index.cfm
  5. Regulations.gov: www.regulations.gov/document/FDA-2018-S-0023-0032
  6. DailyMed: dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
  7. Regulations.gov: www.regulations.gov/document/FDA-2015-S-0024-1317

What this doesn’t establish

Results for one compound don't tell you what the three do together.